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Application order is not arbitrary. The sequence below is based on the chemistry of each formula and the biology of how skin absorbs actives. Follow it exactly for maximum efficacy.
Thinnest to thickest
Always apply in order of texture — from the lightest, most water-based formula to the richest. This ensures each active layer can penetrate before being sealed.
Press, don't rub
Peptides are fragile molecules. Rubbing creates friction that can disrupt the formula and reduce absorption. Press gently with fingertips.
Wait between steps
Each product needs 45–90 seconds to absorb before the next is applied. This is not optional — layering too quickly dilutes each formula.
Clean skin only
Apply all Reni products to freshly cleansed, dry skin. Residue from previous products or makeup will reduce absorption.
Consistency over intensity
Results from peptide-based skincare are cumulative. Twice-daily use for 8–12 weeks produces measurably better outcomes than intermittent high-dose application.
NEUROVÉCTRIX™ Core
Neuromodulating Serum
Texture
Lightweight gel
Wait
45 seconds
Why this order: Applied first on clean skin — peptides require direct contact with the epidermis for maximum absorption. The SNARE-inhibiting peptides work most effectively before any occlusives or emollients.
Application tip: Apply 3–4 drops to forehead, cheeks, and chin. Press gently — do not rub.
View ProductRECEPTORLIFT™
Structural Firming Serum
Texture
Silky fluid
Wait
60 seconds
Why this order: Applied second to allow the peptide layer to absorb fully. Progeline™ and Matrixyl™ Morphomics work at the dermal-epidermal junction — they need to penetrate past the peptide layer, not compete with it.
Application tip: Apply 2–3 drops, focusing on the jawline, neck, and areas of visible laxity.
View ProductSPF Moisturiser
Sun Protection (not Reni)
Texture
Your choice
Why this order: Seal the active layers with a broad-spectrum SPF 30+ moisturiser. This is not optional — UV radiation is the primary driver of extrinsic ageing and will undermine the results of every active you apply.
Application tip: Apply generously and evenly. Reapply every 2 hours if outdoors.
NEUROVÉCTRIX™ Core
Neuromodulating Serum
Texture
Lightweight gel
Wait
45 seconds
Why this order: Repeat the AM application. Neuromodulation is a continuous process — twice-daily use maintains the SNARE complex inhibition effect. PM application also benefits from the skin's elevated repair activity overnight.
Application tip: Same application as AM — 3–4 drops, press gently.
View ProductSTRESSDEFENSE™
Anti-Inflammaging Serum
Texture
Rich serum
Wait
90 seconds
Why this order: Inflammaging — chronic low-grade inflammation — peaks during the day and needs to be resolved at night. Applying STRESSDEFENSE™ in the PM allows Progeline™ and Ectoin® to work during the skin's peak repair window.
Application tip: Apply 3–4 drops. Concentrate on areas of redness, sensitivity, or visible aging.
View ProductDERMASHIELD™
Barrier Renewal Cream
Texture
Velvet cream
Why this order: The final step — a ceramide-rich cream that seals the active layers and supports the skin's barrier repair cycle overnight. Rosaliss™ PSR technology works at the gene level to upregulate filaggrin synthesis while you sleep.
Application tip: Apply a pea-sized amount to the full face and neck. This is your occlusive seal — don't skip it.
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